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Traditional recommendations have called for the use of stepwise addition of medications to metformin to maintain A1C goals

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NAC is also generally safe, with occasional mild gastrointestinal discomfort or headache reported in some users

Preserving metabolically active tissues supports physical function, sustains resting energy expenditure, and reduces the risk of rapid weight regain, thereby enhancing the long-term success and cost-effectiveness of obesity treatments [8, 22,23,24,25]

Bioinformatics (Oxford, England) 30 , 21142120 (2014)