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Immunohistochemical staining and western blot assays revealed increased microglial cells and activated astrocytes in the dentate gyrus of the hippocampus in rats with neuropathic pain, along with elevated expression of TNF-, IL-1, and IL-6 [43, 44]

The appetite suppression wanes

Similarly, another study found a higher rate of progression of proliferative diabetic retinopathy as well as risk of new-onset diabetic macular edema with GLP-1 RAs compared to SGLT-2is

By 2026, anti-diabetics are expected to attract the third highest level of spending after oncology and immunology treatments

As oral GLP-1 formulations become more widely available, and as alternative pricing models continue to evolve, access to these therapies is becoming more modular