Age-related decline (Caplans findings): At birth: ~1 in 10,000 marrow cells are MSCs Teen years: ~1 in 100,000 Age 50: ~1 in 400,000 Age 80: ~1 in 2,000,000 Why perinatal sources: Epigenetic youth Day-one signaling vigor supports robust paracrine orchestration Safety and ethics Not fetal tissue
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[DOI] [Google Scholar] 134.Landaas E.T., Aarsland T.I.M., Ulvik A., Halmy A., Ueland P.M., Haavik J