The secondary evaluation outcomes were alterations in blood urea nitrogen (BUN), uric acid (UA), estimated glomerular filtration rate (eGFR), urinary AKI biomarkers, renal fibrosis biomarkers (transforming growth factor- 1 (TGF- 1 ), connective tissue growth factor (CTGF)), and traditional Chinese medicine (TCM) symptoms
Acknowledgements This study was supported by the grants from Guangdong international cooperation program (2012B050700019) and Guangzhou Enter Nutr Bioscience Co., Ltd
The relatively high affinity displayed by the Gly4( S,S )-ACPC derivative of exendin-4 for the GLP-1R suggests that stable receptor-ligand complexes occur when helical secondary structure extends to the ligand N-terminus, consistent with the consensus conformation of GLP-1R peptide agonists in recent crystal and cryo-EM structures
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M., Burhenne J., Haefeli W