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When administered, it binds to GLP-1 receptors on pancreatic beta cells, stimulating insulin secretion in a glucose-dependent mannermeaning insulin is released only when blood glucose levels are elevated

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This prolonged follow-up substantiates the sustained therapeutic advantage and acceptable safety profile of mRNA-4157 in conjunction with pembrolizumab in surgically excised high-risk melanoma, reinforcing its potential to enhance the efficacy of adjuvant immunotherapy [329]

Science, 2016