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While injectable GLP-1 medications demonstrate significant weight loss of 10-20% through FDA-approved formulations, patches have no substantial evidence supporting their effectiveness

Development of antiobesity medication has not been easy, because of unexpected adverse events

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The Results Participants receiving 7.2 mg semaglutide achieved a mean weight loss of 20.7% at 72 weeks, compared to 17.5% in the 2.4 mg group, and 2.4% in the placebo group. Over 30% of participants on the 7.2 mg dose lost 25% or more of their body weight

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In humans, C-cells contain far fewer GLP-1 receptors, which suggests a much lower risk for similar outcomes