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GLP-1 is a peptide secreted by L-type enteroendocrine cells in the ileum and colon in response to different nutrients, mainly glucose and lipids, whereas glucose-dependent insulinotropic polypeptide is produced by K cells present in the duodenum and the first portion of the jejunum

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But the biggest surprise came when the dose was increased from 1 mg to 2.4 mg per week: not only was blood glucose control excellent, but weight loss was astounding obese people without diabetes lost on average 15% of their starting weight (more than 30 pounds in a person starting at 220 pounds)

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