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While 12 weeks of bright light exposure did not produce measurable improvements in sleep quality, glucose metabolism, or inflammatory markers, it significantly altered clock gene expression in peripheral blood mononuclear cells (PBMCs, specifically decreasing REV-ERB levels and increasing the REV-ERB/BMAL1 ratio)

Therefore, we hypothesized that a BBB-crossing dendrimer nanoformulation double-targeting glucose and glutamine metabolism would be able to impair GBM metabolism and survival

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Increased GSSG or ROS-induced generation of protein thiol radicals both trigger protein glutathionylation