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Mechanistically, glucagon receptor activation promotes hepatic fat oxidation and limits ectopic lipid accumulation

Considering that SOX9 plays important roles in chondrogenic mesenchymal condensation in embryonic limb formation [44] and in directly controlling the expression of various chondrogenic markers such as COL2A1 and ACAN [45, 46], hES-MSCs with high GSH levels also exhibited better chondrogenic differentiation potential

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Its mainly beneficial for patients who cant tolerate newer GLP-1 variants