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As such, glomerular lesions occur which include glomerular basement membrane thickening, podocyte effacement and loss, mesangial expansion, epithelialmesenchymal transition EMT and fibrosis, collagen deposition, damage to the capillary architecture and an influx of inflammatory cells including macrophages

(Marcell Hernyk) and A.P

Thus, the dual penetration enhancer is found most preferred in the present invention

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PLoS Medicine, 4 (5), e158