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Fishbain and Peleg, 2010)

Notably, the specific NLRP3 inflammasome inhibitor MCC950 reduced the expression of AIM2 inflammasome-related genes in high-fat-treated hepatocytes in the same study, suggesting that the inhibitory effects of MCC950 may not be restricted to NLRP3 but could also extend to AIM2 [158]

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Seek GP advice if cold intolerance is severe, worsening, or accompanied by fatigue, hair loss, or other thyroid dysfunction symptoms

But there's no question that most people who go that path will not be doing the stuff that they do now

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