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the mitochondrial cascade hypothesis (19) falls under an antagonistic hallmark
Its availability is restricted to laboratory studies and controlled clinical research investigating metabolic disorders, aging, and exercise physiology
[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Ilic S., Brcic I., Mester M., Filipovic M., Sever M., Klicek R., Barisic I., Radic B., Zoricic Z., Bilic V., et al
In addition, both less and more exercise increase hippocampal pCREB Ser133 -CREB-proBDNF-BDNF signaling and mitochondrial coupling efficiency and could build up long-lasting CREB-BDNF and bioenergetic neural reserves that preserve memory fitness after severe TBI [126]
It even helps reduce gut inflammation by suppressing pro-inflammatory signalling pathways
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