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The study is underpinned by the hypothesis that a high level of therapeutic success can be achieved in patients with IC using a combination of approaches

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Supporting information ACKNOWLEDGMENTS We thank all the participants, investigators and trialsite staff who were involved in conducting the SUSTAIN 15 trials

However, in hyperosmotic stress-treated neuronal cells, Trx1 reduction occurs independently of autophagy and AMPK (137), contrasting with MGO-induced AMPK activation and autophagy (137)

Membranes were washed in PBST, then imaged using the Odyssey CLx imaging system (LICORbio, running Image Studio version 5.2.5), using the 800 nm channel

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