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More than a century ago, patients would get worse and worse until they died

However, a recent placebo-controlled study [13] demonstrated that the DPP-4 inhibitor vildagliptin significantly improved glycaemia (with a lower incidence of hypoglycaemia) in patients with type 2 diabetes with long-standing disease (~15 years) and poor glycaemic control (HbA 1c ~8.4% [68 mmol/mol]) on large doses of insulin (~80 units daily)

These effects are generally mild compared to older weight loss medications and rarely require treatment discontinuation

For angina and arrhythmias, similar dosing schedules are typically followed

These formlulations require less frequent administration, often once weekly

In the main per-protocol analyses we found no evidence that GLP-1RA increased the incidence of SIS (HR 1.04