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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

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AOD-9604 does not affect the hypothalamic-pituitary axis, so there is no negative feedback loop to blunt the response over time

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Individuals have different body types and appropriate injection sites so that the appropriate length will vary