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An in vitro study using GnRH neurons of adult male mice demonstrated that both GLP-1 and Ex4 might excite GnRH neurons, either directly or indirectly by modulating the nitric oxide (NO) and endocannabinoid pathways that control the presynaptic excitatory GABA-ergic inputs to GnRH neurons [36]

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When used as part of comprehensive chronic weight management programs, which include regular physical activity and dietary modifications, semaglutide has proven to be a critical component in managing obesity, diabetes, and associated cardiac conditions

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Weeks 1 to 4: Early Adjustment Phase 3