Over the following weeks most people notice better skin hydration and texture first, plus subtle sleep and energy gains from Epitalon (weeks 13), then visibly firmer, smoother, more even skin (weeks 36), then deeper rejuvenation, elasticity, sometimes thicker hair and nails, with telomere support well established (weeks 612+)
The oxidative stress, antioxidant, and neurochemical parameters, viz., malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), acetylcholine esterase (AchE), dopamine (DA), norepinephrine (NE), and serotonin (5-HT), in the hippocampal and hypothalamic regions have been evaluated
A Cleveland Clinic review notes that one case report described symptoms only after a cumulative 15,000 mcg (15 mg) of injected B12 over several weeks
One major problem, however, is that the histopathological diagnosis itself is not based upon the search of a single (or a few), objective, and easily reproducible morphological diagnostic feature(s) but rather, it is born by a constellation of diagnostic criteria whose implementation, meaning, and relative weight considerably vary case by case and is responsible for a worrisome list of diagnostic pitfalls ( Table 1 )
Can B12 injections improve brain fog in otherwise healthy adults
doi: 10.1152/ajpregu.00634.2009 33
