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To interrogate the mechanisms underlying NRF2-directed regulation of this core gene set, we compared mean promoter (1 kb restricted) ChIP-seq signal in A549 for NRF2, p300, as well as the histone marks H3K4me3 and H3K27ac, which are enriched at promoters and enhancers, respectively

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Alternatively, live green fluorescent protein-incorporated E

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But insulin dose reduction needs to be done carefully and gradually, with close CGM monitoring, to avoid either hypoglycemia (from too much insulin relative to your new needs) or hyperglycemia (from reducing too aggressively)