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The condition can be caused by either excessive production of bilirubin or the livers inability to eliminate it due to various factors such as liver or bile duct inflammation, hemolytic anemia, bile duct obstruction, cholestasis, and Gilberts syndrome

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doi: 10.1161/01.CIR.0000047062.03282.A3

Short-chain fatty acids (SCFAs) are metabolites from gut microbes involved in the hosts inflammatory response and immunity (Yao et al., 2022)

10.1210/endo.142.10.8451 341

DSIP is not appropriate as a first-line insomnia therapy for patients with no metabolic context