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The pivotal clinical trials for tirzepatide (SURPASS programme) did not identify diverticulitis as a specific adverse event of concern, as documented in the European Medicines Agency's European Public Assessment Report (EPAR)

American Journal of Hypertension

doi:10.2337/diabetes.54.7.2212 [DOI] [PubMed] [Google Scholar] 51.Guyatt GH, Oxman AD, Vist GE, et al

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If using at night, pair it with hydrating ingredients but avoid combining it with strong actives like retinol to prevent irritation

There is evidence to suggest that mutations in the MAGEL2 gene may contribute to the characteristic weight gain seen in individuals with PWS