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Author contributions All authors contributed towards data analysis, drafting and critically revising the paper, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work

Membrane-bound TMPRSS2 zymogen undergoes autocleavage activation at the Arg 255 -Ile 256 peptide bond, and the matured enzyme proteolytically activates membrane proteins of the host and invading pathogens (42)

After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10

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For the best results, its important to combine Semaglutide GLP-1 with healthy lifestyle changes, such as a balanced diet and regular exercise

Diabetes and obesity: therapeutic targeting and risk reduction - a complex interplay