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5.1 Intervention strategies 5.1.1 Targeting iron homeostasis Iron chelators such as deferoxamine, deferiprone, and deferasirox bind free ferrous iron (Fe2+), reducing substrate availability for the Fenton reaction and thereby curtailing the lipid peroxidation cascade (152)

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Access this chapter Subscribe and save Buy Now Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others References Azcona C, Preece MA, Rose SJ, Fraser N, Rappaport R, Ranke MB, Savage MO (1999) Growth response to rhIGF-I 80 g/kg twice daily in children with growth hormone insensitivity syndrome: relationship to severity of clinical phenotype