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An 84-year-old woman who had taken oral canthaxanthin for 10 years developed yellow-gold birefringent crystal deposits around the macula visible on a fundoscopic exam

Whats Next: Regulatory filing for weight management: by end of 2025 Submission for type 2 diabetes: expected in 2026 Drug discovered by Chugai, licensed by Lilly in 2018 Implication: Orforglipron could become the first once-daily oral GLP-1 therapy with potent glucose-lowering and weight-loss benefits, potentially disrupting the injectable incretin market.

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In this context, ROS-triggered TP53 activation heightens mitochondrial membrane permeability, leading to the release of pro-apoptotic factors from mitochondria

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Locigno R, Pincemail J, Henno A, Treusch G, Castronovo V