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Adequate protein intake, biotin supplementation, and avoiding excessively rapid weight loss (more than 2-3 pounds per week) reduce the risk

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and dimethyl sulfoxide (DMSO) were acquired from MP Biomedicals (Illkirch, France)

doi:10.1007/s11884-010-0067-2

Get any of those rules wrong and the protein unfolds, loses bioactivity, and becomes useless (and in rare cases, immunogenic)

The answer is that these approaches are often complementary rather than competitive