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Oncogene 38 , 34153427 (2019)

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Resistance Fold was calculated by dividing the IC 50 value of a substrate drug into drug-resistant KB/CV60 cells in the presence or absence of an inhibitor (sertraline, fluoxetine, citalopram, or ONO-1078) by the IC 50 value of parental KB-3-1 cells without an inhibitor

Many research planning windows are shorter 12 to 24 weeks is common for tolerability and titration assessment, with longer cycles for efficacy endpoints