Since degradation of GLP-1 results in an inactive insulinotropic peptide, strategies have been developed to prevent this rapid inactivation for use in the treatment of type 2 diabetes
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With the combined use of structure and medicinal chemistry, several groups have demonstrated that it is feasible to obtain small-molecule PTP1B inhibitors with the requisite potency and selectivity
5.1 Evidence of Cytoskeleton-Directed LD Distribution and Motility Cytoskeletal components and motors have been found on LDs in a variety of organisms, including fungi, plants, and mammals
