H&E assessment The GLP-induced histopathological changes in the thyroid gland were obtained during this research utilizing the basic diagnostic criteria according to AMA protocol: thyroid gland atrophy or hypertrophy (reduced or increased gland size in comparison to the control respectively), follicular cell hypertrophy (cells lining the follicle changed from low cuboidal to columnar or proportion (%) of cells displaying tall columnar change), follicular cell hyperplasia (crowding, stratification and/or papillary formation of single or many layers with % of tissue influenced) and colloid amount (homogeneous or abundant, lacy or scant), other changes (desquamation, inflammatory cell changes, vascularity, others)
The rate-limiting step in extracellular GSH catabolism is controlled by -glutamyltransferases (GGTs), which cleave the -glutamyl bond in GSH to release glutamate and dipeptide cysteinylglycine
10.1186/s13195-018-0451-2 459 VoigtR
This concept is powerful in an in-vitro context, allowing researchers to study the fundamental mechanisms of cellular aging and rejuvenation without the confounding variables of a whole organism
Ethics declarations Conflict of interests The authors declare no competing interests
Think of it as the fuel gauge for your cells
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