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Thus, exogenously administered leptin does not reach the CNS in substantial quantities, a fact that reduces its effectiveness as a drug and hands an advantage to MT-2 even though the effects of the two peptides on melanocortin receptors are nearly identical

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Growth Hormone (GH): As a therapy, exogenous GH directly supplements the bodys natural hormone, providing a specific and potent effect on growth and metabolic processes

Additionally, aging is associated with decreased insulin sensitivity, as well as other metabolic changes that contribute to insulin resistance