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Body cells and tissues are threatened continuously by damage caused by toxic free radicals and reactive oxygen species

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224 Mechanistically, mGluRs can directly regulate glutamatergic signalling by anchoring in complexes with SHANK and HOMER proteins and further control the synthesis of synaptic proteins via activation of the PI3K/AKT/mTOR pathways

In some cases, temporary dose reduction or treatment interruption may be appropriate while addressing hydration status, with subsequent cautious re-titration once symptoms resolve

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