a , Body weight of Control, Bmal1 -KO, and Bmal1 -KO + NDI1 mice at 4 months of age on a chow diet (n = 7 Control, n = 6 Bmal1 -KO, and n = 5 Bmal1 -KO + NDI1)
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doi: 10.1210/jcem.74.6.1375600 35 ChenJWHojlundKBeck-NielsenHSandahl ChristiansenJOrskovHFrystykJ
The SUMMIT trial below evaluated the effects of tirzepatide in obese patients with HFpEF
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IV is preferred due to variable oral bioavailability (discussed further below)