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Nonresponders For all current vaccines, there is a significant population of individuals who are considered nonresponders (i.e., nonseroconverters), particularly those with an inability to mount effective B-cell responses

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Human papillomavirus (HPV) is the primary etiological agent, driving lesion progression from low-grade cervical intraepithelial neoplasia (CIN1) to high-grade neoplasia (CIN2/3) and microinvasive lesions, ultimately leading to invasive cervical cancer (Spitzer, 1998)

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