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C-Terminal Amidation (-NH2) C-terminal amidation helps protect the peptide from carboxypeptidase-mediated degradation, increasing overall molecular stability

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Wednesdays results also add to the growing body of evidence that point to the therapeutic value of GLP-1 therapies beyond diabetes and weight lossparticularly their protective potential against addictive disorders

In addition, exendin-4 treatment repressed mitochondrial dysfunction, as shown by lower levels of the mitochondrial function-associated genes MCU and UCP3, as well as the mitochondrial fission genes DRP1 and FIS1

doi: 10.1016/j.biopha.2019.108667 53 KrasnerNMIdoYRudermanNBCacicedoJM

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