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Similarly, in colorectal cancer stem cells, p300-mediated H4K12la upregulates glutamate-cysteine ligase catalytic subunit (GCLC), thereby expanding the GSH pool and conferring ferroptosis resistance (116)

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[PubMed: 30098321] 77

Traditionally, pine bark has been used for their anti-inflammatory and wound healing effects (57, 61)

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Although TNF at this dose exerted no cytotoxic effects, H 2 O 2 pretreatment resulted in marked cell death in both HepG2 cells and NCTC1469 cells in response to TNF challenge (Fig