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The synthetic ingredient higenamine is not a legal dietary supplement, although it may appear naturally in a variety of plants including Nandina domestica, which is commonly used in throat lozenges in Japan

doi:10.3390/nu11092073 Wu G, Fang YZ, Yang S, Lupton JR, Turner ND

National minimum retesting intervals in pathology [Internet]

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Not WADA or IOC approved

Puskarich MA, Jones AE (2024): Epinephrine