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Based on current available data for mass market dietary supplements

Medically Reviewed by: Dr Kanika Raina, BDS, MBA (Hospital & Healthcare Management) Last reviewed: February 2026 References: Katsi V, Koutsopoulos G, Fragoulis C, Dimitriadis K, Tsioufis K

doi: 10.1111/bph.12895 107 ZhaoDLiuJWangMZhangXZhouM

The theoretical difference comes from retatrutide's glucagon activity

The two biggest reasons were that the medication wasnt available at their pharmacy and that many patients didnt have coverage and couldnt afford the $1,000-or-more price tag

Your clinician will advise you that to gain the full benefit of Wegovy treatment, youll need to follow a diet and exercise plan