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Some SGLT-2 inhibitors are also FDA-approved for use in people with chronic kidney disease (CKD) and/or heart failure to lower the risk of heart attack, stroke, and/or heart failure flare-ups, including in people who do not have diabetes

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It is worth noting that about 40% of RA patients suffer from complications, and the incidence of serious complications is 8.3%, with cardiovascular disease, interstitial lung disease, osteoporosis, and metabolic syndrome predominating (Taylor et al., 2021)

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