In contrast, the non-metabolizable glucose analogue 2-deoxy-D-glucose (2-DG) inhibits glycolysis and significantly reduces lactylation levels [37, 38]
Ensure ice packs do not contact the vial directly, as this could cause localized freezing
Chovanov et al., 2006
However, the brain is highly susceptible to oxidative damage due to its high oxygen consumption and limited antioxidant defenses (Sies et al., 2017)
Besides triggering a sequence of events that cause toxic outcomes, exposure to xenobiotics leads to induced oxidative stress, generating an over production of reactive oxygen species (ROS) [49] and consequently triggering oxidative damage to macromolecules such as proteins, lipids, and nucleic acids [50, 51]
Inhibition of abnormally activated HIF-1-GLUT1/3-glycolysis pathway enhances the sensitivity of hepatocellular carcinoma to 5-caffeoylquinic acid and its derivatives