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In type 2 diabetes, postprandial GLP-1 secretion may be reduced , leading to an impaired insulin response

The recommended approach is still to start retatrutide at 2mg regardless of your previous tirzepatide dose

doi: 10.1126/science.abe9985

It's worth noting that feeling cold can also be caused by other conditions unrelated to weight loss, such as iron-deficiency anaemia, vitamin B12 or folate deficiency, or an underactive thyroid

Additionally, the pricing can be confusing since they state the price of the medication, but its not clear if its per week or per month

Lifestyle adjustments that support digestion include modest post-meal activity, upright posture after eating, sleep hygiene, and stress-reduction techniques that modulate gut-brain sensitivity