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It is essential for patients to remain well-hydrated, aiming for at least 2 liters of water daily, as dehydration can exacerbate feelings of fatigue

They are able to internalize tumor cells and blood (F3) or lymphatic (LyP-1) endothelial cells in the tumors they home to

It is also known to mediate the migration of endothelial cells [97]

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10.1016/j.clnu.2021.04.028 131

These models allow the investigation of molecular pathways underlying tumorigenesis and cellular processes driving nodule formation, providing critical insights into the pathophysiology of thyroid cancer