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Baik JY, Liu Z, Jiao D, Kwon HJ, Yan J, Kadigamuwa C, et al

[6] The concern with any unregulated IGF-1R agonist is precisely that it could stimulate the survival and proliferation of pre-neoplastic or neoplastic cells, which is why IGF-1R has been an oncology drug target for inhibition rather than activation

3.0%6.6% and 0.4% of patients in the respective groups discontinued treatment because of these adverse events (54)