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The reaction mechanism is as follows: GSSG + NADPH + H 2 GSH + NADP (catalyzed by GR) It's worth emphasizing that the GSH/GSSG ratio is a crucial indicator of cellular redox status

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In the case of T98G cells, regardless of whether metformin or simvastatin was used alone or in combination, a significant decrease in membrane potential was observed, consistent with the increase in apoptosis induced by metformin and simvastatin as mentioned earlier ( Fig

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