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119 Furthermore, fumarate accumulation can activate the PI3K/AKT signaling pathway through PTEN succinylation, exerting oncogenic effects

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OTA was found to chelate ferric ions (Fe 3 ), facilitating their reduction to ferrous ions (Fe 2 ), which in the presence of oxygen, provided the active species initiating LPO [74]

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During these processes, GSH is converted into its oxidized form, glutathione disulfide (GSSG)

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