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Interestingly, these results suggest that in the absence of adverse cardiac remodeling and systolic dysfunction by echocardiography, there are still ventricular hemodynamic abnormalities consistent with an altered ability of myocardium to relax properly during diastole, despite no change in afterload, indicating a direct effect on the myocardium

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The addition of glucagon receptor agonism introduces some safety considerations not seen with GLP-1 or dual GLP-1/GIP agonists alone

Regulations of nuclear membrane damage through reduction of tail length (which is amount of DNA released from nuclei entering comet tail) was reported against genotoxicity of Al in Brassica juncea [92]