Clinical data with these newer agents (incretin mimetics and DPP-IV inhibitors) have shown fewer treatment limiting side effects, with either no effect on body weight while improving glycemic control (DPP-IV inhibitors), or decreasing body weight with improved glycemic control, as is the case with incretin mimetics (liraglutide and exenatide)
Like other side effects, semaglutide heartburn tends to be dose-dependent
That number dropped from 16 in October 2025 after California, New Hampshire, Pennsylvania, and South Carolina eliminated obesity GLP-1 coverage largely due to state budget constraints
Reapply frequently to boost effects
FDA regulatory context: As of May 2026, the FDA has proposed excluding compounded semaglutide and tirzepatide from the 503B Bulks List, with a public comment period closing June 29, 2026
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