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Clinical trials The ongoing Phase 3, open-label VERITAC-2 trial (NCT05654623) is evaluating vepdegestrant as monotherapy in patients with ER-positive, HER2-negative advanced or metastatic breast cancer that was previously treated with a CDK4/6 inhibitor plus endocrine therapy

The standard dosing regimen begins with 3 mg once daily for one month, increasing to 7 mg daily, with a possible further increase to 14 mg daily if additional glycaemic control is needed

Participants in this clinical trial lost an average of 15.3 kg

Furthermore, Bae et al