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Individuals with advanced alcoholism frequently present with clinical liver disease while reporting low perceived intoxication levels, precisely because neuroadaptive tolerance has altered CNS GABA-ergic and noradrenergic baseline signaling

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In conclusion, This present study demonstrated that VPA inhibit the gene and protein expression of -FAO enzymes via PPAR signaling, resulting in suppression of -FAO, oxidative stress, and specific ACs accumulation

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Post hoc analyses suggest potential sex- and age-dependent effects, warranting confirmation in larger, adequately powered studies