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Delayed response can reflect suboptimal dosing, undiagnosed lifestyle barriers, or genetic variants that reduce GLP-1 receptor sensitivity

6 In the EXAMINE trial, a safety signal for increased risk of hospitalisation for heart failure was identified with alogliptin, particularly in people with a history of heart failure

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GLP1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NFkappaB signaling pathways in streptozotocininduced diabetic rats

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