Specifically, CYP3A4 and CPR genes were cloned into HAC vectors in CHO cells using the Cre-loxP system, and then CYP3A4-CPR-HAC was transferred to Caco-2 cells by chromosomal transfer technology (Ohta et al., 2020)
Read that background separately from this news update: the regulatory status described here is tied to the July 23 committee result and can change again when FDA acts
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