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However, the presence of excessive oxygen or limited oxygen can lead to fatal toxicity of cells (36)

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Moreover, the 2017 Cell paper revealed FOXO4-DRI was able to lower the cellular senescence induced by chemotherapy treatment Doxorubicin: doxorubicin-induced senescent cells showed an upregulation in FOXO4 foci and FOXO4-DRI potently and selectively lowered the viability of doxorubicin-senescent versus control IMR90

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Mistake 3: reducing the dose when side effects occur instead of holding steady When nausea or other GI symptoms appear after a dose increase, some researchers immediately drop back to the previous dose

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