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Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is expected to be regained over the next 5 years [4, 5]

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This common concern affects many patients starting glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), or dulaglutide (Trulicity) for type 2 diabetes or weight management

Clinical Evidence Comparison Prescription GLP-1 medications have been studied in large-scale clinical trials with thousands of participants, demonstrating significant and reproducible effects sufficient for FDA approval